Antidiabetic and Antioxidant Effects of Newly Synthesized Pyrimido[1,6-a] Pyrimidine Derivatives in Neonatal Streptozotocin-Induced Diabetic Rats

Synthesis of some novel pyrimido[1,6-a]pyrimidine derivatives 4, 8 and 10 was described through the respective reactions of sodium salts of formyl ketones 1, 7 and 9 with 6-aminothiouracil. The characterization of the reaction products was confirmed by using the available elemental analysis and spectral data. One of these derivatives (4b), 1-thioxo-1,2,7,8,9,10-hexahydro-3H-pyrimido[1,6-a]quinazolin-3-one, was tested using sublethal dose level (10 mg/kg b. w./day for 3 weeks) and was found to have potent antihyperglycemic, antihyperlipidemic and antioxidant properties in neonatal streptozotocin-induced (n-STZ) diabetic male and female albino rats. *Corresponding author: Osama Mohamed Ahmed, Zoology Department (Physiology Division), Faculty of Science, Beni-Suef University, Egypt; Tel: 0020101084893; Fax: 0020822334551; E-mail: [email protected] Received January 26, 2012; Accepted February 23, 2012; Published February 24, 2012 Citation: Ahmed OM, Hussein AM, Ahmed RR (2012) Antidiabetic and Antioxidant Effects of Newly Synthesized Pyrimido[1,6-A]Pyrimidine Derivatives in Neonatal Streptozotocin-Induced Diabetic Rats. Med chem 2: 020-028. doi:10.4172/21610444.1000108 Copyright: © 2012 Ahmed OM, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.